Methylation

Methylation

The doctors at Health and Wellness of Carmel feel it is important to consider many variables in designing your unique, personalized wellness plan. We evaluate you for hormone imbalances, environmental toxicities, nutritional deficiencies, PH imbalances, mineral imbalances, and your biological terrain. Rather than forcing patients into the “one- size fits all” chemical strait-jacket of medications (and their side-effects), we actually treat the problem from its root cause. Specifically, the doctors utilize individually tailored nutrients to correct the underlying imbalances. Using a careful interview and thorough physical exam, we are then able to analyze insurance covered labs that help us identify your unique bio type. Using the concepts developed by Ortho Molecular© medicine, it is possible to see profound changes in one’s health when one begins a personalized nutritional supplement protocol.


Why are physicians so excited about methylation status??

The methylation pathway influences many biological systems in our body. One example would be a specific biotype known as pyrole disorder. This biotype leads to low stress tolerance, white spots on nails, tendency towards anxiety, and food sensitivities. It is treated with a unique combination zinc, B6, and primrose oil. Another example would be, undermethylation (histadelia). These patients often have severe depression, and may have a tendency toward aggression and perfection. Frequent colds and allergies are noted as well. Patients respond very well to methyl donors such as SAMe, TMG, and L-Methionine. Another example would be overmethylation (histapenia). These patients would have a tendency towards dental caries and ringing in the ears, unexplained body pains, and arthritis. They frequently have severe food allergies, easily fatigued and frustrated. These patients respond to methyl blockers, such as, Niacin, B12, and DMAE. By carefully monitoring bio markers such as, ammonia, histamine, homocystine, RBC folate, RBC zinc, RBC copper, you can continuously adjust the regimen until optimal methylation status is achieved.

The new science of nutragenomics

Methylation is the message

Methyl groups are the body’s messengers and movers and shakers. They join with other compounds to “jump-start” a reaction (such as turning a gene on or activating an enzyme). When the methyl group is “lost” or removed, the reaction stops (or a gene is turned off or the enzyme is deactivated), OR when a methyl group is lost a gene is turned on (for example, a gene related to cancer) when it is not ideal to have it turned on.


The complexity of modern ailments

In addition to the rising number of chronic conditions such as, diabetes, heart disease, arthritis, chronic fatigue, doctors are now seeing a myrid of new syndromes such as, FM, CFS, Chemical sensitivity, PANDAS, etc. Many people are facing the fact that these disorders aren’t as easy to “fix” as we first hoped they would be back in the 1950s. Where once people felt assured that the right drug could combat almost any disease, we are just beginning to understand that health conditions are more complex than that and do not occur as an isolated incident or event. There is no panacea, no magic cure, nor do most conditions arise from just one cause, like a hostile bug or toxin. Many different factors act together to influence their development; and as our understanding of their complex origins changes, so does the manner in which we address them. Still, most people and even many doctors find the complexity confusing, as they have to face up to the reality that the days of simple treatments and health guarantees are behind us. So is the time where we could entirely entrust our health with experts. As a result, many more people have decided to take matters into their own hands. In this new territory, people need solid information and a road map, with clear directions they can follow to journey toward healing. This is one of our goals at Health and Wellness of Carmel. Ideally, we will encourage you to obtain a simple saliva test so that we can analyze your own unique genetic variability.

The Alphabet of Genes

In nutrigenomic testing, we are able to identify changes in the “spelling” of the genetic basis. These spellings are a short hand used by scientists which deploy the letters A, t, c, MG to designate each ¼ of genetic basis. They combine in various ways. These four bases are organized into a particular sequence to create or “spell” every single one of the genes in the body. Taken together, these bases make up all of our DNA. To understand this further, let’s take a deeper look at the tasks performed by each gene. That task will differ depending upon the functional area that the gene impacts. A change in the gene will change the action of the enzyme, catalyst, or activity. Enzymes do many different things. Certain enzymes join together to make components needed to perform a particular task. Other enzymes may break down one biochemical or transform it into another. Enzymes also pick up speed and efficiency with which these tasks are performed. Biochemical actions can also be slowed down or accelerated by genes. One example would be many people feel overstimulated and have trouble going to sleep if they drink caffeine before bedtime. On the other hand, some individuals possess a biochemistry that can handle it. Just as the caffeine “speeds up” one’s energy, certain SNPs “speed up” or “slow down” certain biochemical functions. Accelerated activity can be more efficient, or can produce undesirable effects. By identifying the presence of a SNP, we can compensate for it, and give the body the support it needs to perform its tasks successfully. Briefly, all individuals carry at least a single mutation in the methionine folate pathway. As a result of decreased activity in the methylation pathway, there is a shortage of methyl groups in the body that would otherwise serve a variety of important functions.

Defects in the methylation cycle lay the ground work for further assault by environmental and infectious agents, resulting in a wide range of conditions.

Promoting detoxification safely by optimizing the methylation cycle

Many bodily systems act together to remove harmful substances or waste. But if these processes are not operating effectively, or we absorb more toxins than our system can handle, our body will store them, eventually creating a toxic overload that acts as a prime contributor to ill health. Methylation helps to keep toxins and foreign substances at safe levels where they cannot harm the body. A core principle of naturopathy and other forms of holistic healthcare is to give the body what it needs and to remove from the body whatever causes harm or imbalance. What is the scope of the problem? The last century was the golden age of chemistry. White coated scientists worked in in labs synthesizing a continuous stream of novel substances. Many products now widely used in food agriculture never existed before this revolution in chemistry. As a result, human beings and the earth itself have been exposed to a wide range of new substances. None of us keep a tally of how many of them we have absorbed over our life time. Safety studies only look at toxicity for single elements and no one has looked at evaluating the bodily effects of carrying multiple toxins simultaneously. We have unintended synergies that multiple chemicals interact in novel ways potentially causing serious problems. These safety assessments do not look at the many kinds of interactions that are occur outside of the controlled lab environment, in real life, in our bodies. As a result, there is much that we do not know about the bodily impact from novel ingredients. But our body knows. And our body lets us know that it has more than it can handle by creating a health symptom or condition. The cumulative toxic overload is one of the reasons we believe there is such a growing rate of symptom complexes and degenerative diseases.

How do the doctors interpret the nurtigenomic tests?

When reviewing the report of the methylation Gene SNPs, the doctors will note which genes have homozygous mutations (++) and which have heterozygous mutations (+-). Individuals who have a double homozygous mutation may have a more pronounced dysfunction at that gene.